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Times article on use of the Interim Cancer Drug Fund

Only 200 patients helped by £50m fund for extra cancer drugs

Only a tiny proportion of the Government’s interim fund for cancer drugs has been claimed, almost a third of the way through its six-month lifespan, The Times has discovered.

The £50 million emergency fund for drugs not approved by the NHS watchdog has been used for only 200 patients, with doctors finding the application process bureaucratic and confusing.

Wide regional variations also emerge from figures obtained by The Times from regional strategic health authorities, with experts warning of a return to a “postcode lottery”. For example, while the NHS in the West Midlands has paid out £500,000 from the fund on 22 patients, in the South Central region only £38,000 has been spent on ten patients.

The fund allows doctors to pay for expensive cancer drugs that have not been deemed cost-effective by the National Institute for Health and Clinical Excellence.

Before the general election David Cameron promised a £200-million-a-year cancer drugs fund to allow these drugs to be prescribed on the NHS. The interim £50 million, which opened in October, will be available until the main fund begins in the spring. However, figures compiled from England’s ten NHS regions show that only about 200 people have been treated under the scheme nationwide, a tenth of independent projections, while in Yorkshire the number of applications is in single figures.

About £2 million, 4 per cent of the total, has been spent in the five regions which revealed spending figures. The remaining regions have had similar numbers of applications, suggesting that well under 10 per cent of the £50 million has been claimed.

Experts said that many doctors did not understand how to access the scheme, while others did not want to use it. A survey of hundreds of oncologists carried out by Professor Lesley Fallowfield of the Univeristy of Sussex said: “Many of the doctors had no idea what the policy of their trust was. Many doctors are still uncertain because it’s somewhat ambiguous as to what the process is.”

Different areas have the power to allow different drugs, with Avastin, a cancer drug rejected by Nice, automatically available under the fund in some parts of the country, but not in others.

Professor Fallowfield, a psychologist who studies how cancer is treated, said: “The process to access this fund is still unclear and my anxiety generally is that panels in different SHAs are making their own idiosyncratic decisions.”

She said there was a danger that those who “shout the loudest” could get treatment, not those who need it most.

Doctors also felt that they should put their responsibility to the wider NHS ahead of individual patients, the survey found, meaning that they often did not want to apply for unapproved drugs.

“Many doctors were thinking ‘I’m not sure that NICE hasn’t made the right call’,” Professor Fallowfield said.

A spokesman for the Department of Health said it was monitoring applications and would assess the fund in April.

COST AND EFFECT

Avastin (Bevacizumab) In advanced bowel cancer, can prolong life by six weeks on average, but NICE ruled £21,000 per patient was not cost effective.

Azacitidine In rare cancers of the blood and bone marrow, shown to extend life by nine months on average, but NICE provisionally ruled that £45,000 a head was too much.

Imatinib Used on chronic myeloid leukaemia and intestinal tumours, but NICE said there was not enough evidence to justify £19,500 per patient to give it to people whose tumours had been removed.

Temsirolimus (Torisel) Not approved for patients with kidney cancer.

Source: The Times – 22/11/2010


Interim Cancer Drug Fund – how does it work?

Latest update on how the Interim Cancer Drug Fund will be implemented at your local Strategic Health Authority level.
Check your SHA guidelines availability of azacitidine.
Information is published by the Rarer Cancers Foundation website.


Macmillan Pre-election Campaign

Please take part in the current Macmillan campaign, as their priorities are very closely linked to MDS issues:

“The next Government has the power to invest in the future of cancer care. We need every parliamentary candidate to make a firm commitment to cancer support, and you can make this happen.

It only takes two minutes to send the template email to your local candidates, asking them to support our three calls on cancer.”

Click here to access the webpage: Macmillan campaign for parliamentary candidates


NICE rejects azacitidine again in their latest draft guidance

In preliminary draft guidance issued for public consultation NICE has not recommended azacitidine (Vidaza, Celgene) as a treatment option for people who have the following conditions, and are not eligible for haematopoietic stem cell transplantation: intermediate-2 and high-risk myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemia.

The committee decided that although azacitadine was shown to be clinically effective, the benefits to patients could not justify the high cost of the drug.

This draft guidance has been issued for consultation. NICE has not yet issued final guidance to the NHS.

Publication of this second appraisal consultation document follows the return of the appraisal to the independent Appraisal Committee after appeals against the Institute’s final appraisal determination were partially upheld. The appeals were received from the manufacturer of azacitidine (Celgene), a joint appeal from the Royal College of Pathologists and British Society of Haematology, a joint appeal from the Leukaemia Society, Rarer Cancer Forum and MDS UK Patient Support Group and one from the Royal College of Physicians Medical Oncology Joint Special Committee.

The Appeal Panel requested that the Appraisal Committee reconsider the guidance, taking account of a wider range of comparators than originally considered. The Appeal Panel also suggested that the Appraisal Committee examine data on quality of life submitted by MDS UK.

NICE Chief Executive, Sir Andrew Dillon said: “The independent Appraisal Committee reconsidered the evidence on the effectiveness of azacitidine, when compared with best supportive care and low-dose chemotherapy. They also considered the additional data submitted by MDS UK on quality of life. However, the Committee again concluded that the drug could not be recommended as a cost effective use of NHS resources. This is a very expensive drug, even with the small discount offered by the manufacturer.”

“Although we are very disappointed not to be able to recommend this treatment, we have assessed it fairly and on precisely the same basis as other drugs used for rarer conditions.”

Myelodysplastic syndromes (MDS) are a group of bone marrow disorders, where the marrow doesn’t produce enough of one or more types of blood cells. The majority of patients with MDS receive best supportive care in current clinical practice and some patients receive low dose chemotherapy. There are approximately 700 patients with MDS in England and Wales.

Notes:

  1. The guidance is available here.
  2. According to the manufacturer’s estimates, azacitidine costs approximately £45,000 per patient.
  3. The manufacturer of azacitidine has agreed a patient access scheme with the Department of Health, in which azacitidine for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemia will be available with a 7% reduction in the acquisition cost.
  4. The committee agreed that azacitidine did fit the criteria to be considered under the supplementary advice for end of life medicines; however, the magnitude of additional weight that would need to be assigned to the original QALY for the cost effectiveness of the drug to fall within the current threshold range would be too great, even when the patient access scheme was incorporated.
  5. The committee agreed that the most plausible ICER for azacitidine in the overall patient population was approximately £59,000 per QALY gained.

NICE Final decision to NOT RECOMMEND azacitidine for MDS patients

4th March 2010 – NICE has just issued their FINAL decision on the cost-effectiveness HTA for azacitidine (Vidaza). They DO NOT recommend the use of the drug for NHS patients.

Continue reading…


Please Support Our NICE Campaign Appeal

On 4th March 2010, NICE published their final decision not to recommend the use of azacitidine (Vidaza) to treat patients with MDS in the NHS, despite its proven ability to extend patient survival and significantly improve quality of life.

MDS UK Patient Support Group is one of the groups appealing the NICE decision on 1 June 2010.

Please sign a petition asking the Prime Minister to ensure treatment for MDS patients in the UK matches the rest of Europe.

Check our campaigns page for more ways you can help out before the appeal on 1st June 2010.

Please sign a petition asking the Prime Minister to ensure treatment for MDS patients in the UK matches the rest of Europe.

Check our campaigns page for more ways you can help out before the appeal on 1st June 2010.


Petition News

Prime minister’s office responds to the AML (Acute Myeloid Leukaemia) petition for azacitidine:

Continue reading…


Recent Press Coverage

The government’s drug rationing body, NICE, is to be stripped of its power to turn down new medicines for use in the NHS.

Nice to lose powers to decide on new drugs  Guardian article who first reported the news on Saturday 30th October 2010

Drug victory for patients: ‘Penny-pinching’ NICE stripped of power to ban life-saving drugs  Daily Mail article 1st November 2010

Awareness of rarer cancers Further article by John Leech MP – who tabled the adjournment debate on Rarer Cancers and MDS on the 26th October in Parliament. He also tabled an EDM (Early Day Motion).

Disappointment as Vidaza appeal fails to sway NICE rejection  PharmaTimes article on latest NICE decision 4th November 2010 –


Latest news: AML vaccine research and trial

“Scientists at King’s have developed a vaccine treatment for Leukaemia that can be used to stop the disease returning after chemotherapy or bone marrow transplant. The vaccine is due to be tested on patients for the first time. Eventually it is hoped the drug, which activates the body’s own immune system against the leukaemia, could be used to treat other types of cancers. ” KCL website.

Continue reading…


Press articles about CML patient being denied access by NICE to drug he needs

This CML (Chronic Myeloid Leukaemia) patient is facing similar issues as our MDS patients with azacitidine, as NICE’s preliminary decision is NOT TO recommend 2 drugs that can treat this condition. Continue reading…


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