MDS Current Trials UK

We aim to list an easily understandable description of any MDS clinical trials currently opened to recruitment in the UK.

Patients will be able to read up on the details of these trials and use this information to discuss with their consultants or nurses. If you'd like more information about what a clinical trial is and how it is conducted, please go to this section or download our Clinical Trials factsheet.

Not all patients can be enrolled in drug trials - as not every patient will fit the necessary inclusion criteria, which need to be followed very strictly. However, if a particular clinical trial drug is considered an option by the haematologist, it is sometimes possible to obtain the drug outside the trial, on the basis of compassionate use.

MDS Clinical Trials

The AMMO Trial

The AMMO trial will test a new drug called ASTX727 to see how effective it is at treating and extending/improving the lives of people with MDS/MPN Overlap Syndromes, such as CMML. The trial is a comparison of response to treatment of patients taking ASTX727 versus best supportive care.

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  1. SUB-TYPE OF MDS: All subtypes of MDS.
  2. SEVERITY OF MDS: High Risk MDS and Acute myeloid leukaemia.
  3. NAME OF DRUG: CCS-1477
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  1. SUB-TYPE OF MDS: All Subtypes
  2. SEVERITY OF MDS: Intermediate, High or Very High Risk
  3. NAME OF DRUG: Venetoclax
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  1. SUB-TYPE OF MDS: Patients with relapsed/refractory AML or AML secondary to myeloproliferative neoplasm.
  2. SEVERITY OF MDS: Intermediate, High or Very High Risk
  3. NAME OF DRUG: KRT-232
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