REDDS13 Aug. 2018
Research FOR Patients
-For an informed and empowered opinion-
All the trials listed on our site have been properly vetted for scientific accuracy. Many thanks to Dr Simone Green – Hull and East Yorkshire Hospitals NHS Trust - for the continuous work in updating the listing.
REDDS IS NOW CLOSED TO RECRUITMENT
Following this study the investigators now have the information needed to progress to a definitive trial of different red cell transfusion strategies to determine effectiveness and safety.
- SUB-TYPE OF MDS: All MDS patients who are transfusion dependant
- SEVERITY OF MDS: All
- INVESTIGATIONAL INTERVENTION: Blood transfusion support
- Aims and benefits: This is a randomised, single-blind, controlled trial comparing quality of life in patients with MDS transfused to two different haemoglobin levels.
- Group A - Restrictive transfusion strategy
- Group B - Liberal transfusion strategy
- Basic inclusion criteria:
- All patients with MDS ≥ 18 years of age and with < 20% blasts on bone marrow aspirate (including non-proliferative CMML and other MDS/MPN overlap diseases)
- Transfusion dependent: at least 1 red cell transfusion episode per month in the last 8 weeks
- Life expectancy >6 months
- Basic exclusion criteria:
- Unable, in the opinion of the attending clinician, to tolerate restrictive or liberal red cell transfusion thresholds
- ECOG performance status ≥ 3
- Patients being actively treated with erythropiesis stimulating agents (ESAs) or disease modifying agents for their MDS (such as lenalidomide, azacitidine, hydroxycarbamide, experimental agents)
- Patients with myelofibrosis
- Patients in whom the attending clinician considers that active bleeding or on-going haemolysis contribute significantly to the cause of anaemia
- Patients presenting with splenomegaly >5cm below the costal margin
- Trial sites/locations and name of physician in charge of trial: Royal Bournemouth Hospital; Aberdeen Royal Infirmary; Great Western Hospital; Nottingham University Hospitals NHS Trust; St James Hospital, Leeds; Churchill Hospital, Oxford; Birmingham Heartlands Hospital; Freeman Hospital, Newcastle; Salisbury Hospital
- More information:
Please read information and always discuss trial information with your own physician.