Imatinib mesilate treating MDS

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Graham
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Imatinib mesilate treating MDS

Postby Graham » 04 Apr 2013 18:14

According to European Medicines Agency orphan status was granted for the treatment of myelodysplastic/myeloproliferative diseases.

Imatinib mesilate is authorised in the European Union for treatment of adult persons with myelodysplastic diseases according to European Medicines Agency

Imatinib has been in the news lately as cheaper generic versions are now allowed to be produced in certain counties. (India)

Has anyone ever been treated for MDS as by way of a trial or otherwise with Imatinib and if so what were the results.

Good results have been achieved and reported for sufferers of leukemia in extending life expectancy , could the same results be achieved for MDS.

I would be interested in any comments.

Graham
I have moved into the High risk category of MDS RCMD. I am transfusion dependent with zero neautrophils and very low Platelets. I have undergone 6 month course of Azacytidine with disappointing results.
chris
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Joined: 01 Dec 2009 21:52
Location: Essex
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Re: Imatinib mesilate treating MDS

Postby chris » 04 Apr 2013 20:47

HI Graham

Yes, I heard that on the news too and my ears pricked up!! As I understand it, there are only a small number of leukaemia and MDS patients (CMML mainly I believe) with a certain specific type of chromsomal abnormality that respond very well to this drug - also called Gleevec. Here's a link. But personally, no experience and I have not heard of trials of this drug for MDS generally

http://www.lls.org/content/nationalcontent/resourcecenter/freeeducationmaterials/leukemia/pdf/cmmljmml.pdf

Have a peruse.

Best wishes

Chris
Chris. (F) Age 65. MDS diagnosed in 2008. Closest sub-type is CMML-1 but with anomalies! Normal red cells, low white cells and platelets, slightly raised monocytes. Enlarged spleen. No current treatment - active monitoring 3-
monthly.SE Essex

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